منابع مشابه
Dothiepin dependence syndrome.
Sir, Clinicians have depended on antidepressants for years in the management of depressive disorders Drug abuse involving antidepressants is not common, most of them involve agents with amphetamine like proper ties, including amineptine and tranylcypromine.1 Amineptine dependence and tianeptine abuse has been well documented.2 No case report related to dothiepin abuse has been documented till d...
متن کاملAn exceptional reaction to dothiepin (prothiaden).
Dothiepin (prothiaden) is a tricyclic antidepressant related to amitryptylline. Pharma¬ cologically each 25 mg dose is the equivalent to 22-2 mg of 11.(3 dimethylamino propylidene) 6-11.dehydrodibenythiepin. While used for some ten years in Europe, many of the reports are Austro-CzechovakiaPolish in origin, it is still relatively new in this country. The formulation makes its anti¬ depressant p...
متن کاملDothiepin, Qt Prolongation and Torsades De Pointes
A case is reported of electrocardiographic QT prolongation that was presumbty familial in origin. Torsades de points developed in association with the use ofdothinepin, despite the pmscription of a low dose of this drug.
متن کاملEffect of dothiepin on nociceptive response in diabetic rats.
In alloxan-diabetic rats of 4 wk duration with blood glucose levels of about 300 mg/100 ml, the tail flick reaction time (TFRT) to thermal stimuli was significantly elevated (P less than 0.25), indicating hypoalgesia. Intraperitoneal dothiepin, injections of 25 mg & 50 mg/kg body weight per day did not significantly alter the TFRT, either in control or in diabetic rats, following either acute (...
متن کاملA Comparative Evaluation of Dothiepin (prothieden) and Imipramine
A double-blind controlled comparative trial of Dothiepin was carried out in Psychiatric Hospital, for comparing its efficacy with that of Imipramine, in the treatment of depression and also to compare the incidence and severity of side effects of the two drug;. Dothicpin hydrochloride is a tricyclic anti-depressant drug with pharmacological properties common to Imipramine Amitryptline and relat...
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ژورنال
عنوان ژورنال: BMJ
سال: 1995
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.311.7018.1502b